Selden Street between Second and Third is Anthony Lombardo's block now. SheWolf Pastificio & Bar, his Rome-inspired Italian restaurant, opened in 2018 and was Hour Detroit's 2020 Restaurant of the Year. He is a two-time James Beard Best Chef Great Lakes semifinalist.
Last year he started traveling Sicily seriously, on his fourth or fifth trip he stopped pretending he was researching a dish and admitted he was researching a restaurant. Medusa is the result.Medusa Cucina Siciliana opened January 15, 2026, at 644 Selden, one block west of SheWolf. The space had killed three concepts before (Smith & Co., Vigilante Kitchen + Bar, Epiphany - Nain Rouge Kitchen).
The room is light, airy, white walls with blue accents, exposed brick painted the same color as everything else so the eye stops focusing on it. The bar wraps three sides with about twenty seats around it. Patrick Thompson Design did the interior.
The name comes from the gorgon at the center of the Sicilian flag.Sicily is the menu. Lombardo and executive chef Scott Overall, his former SheWolf chef de cuisine, want to drag anchovies back into the Detroit dining conversation. Lombardo's stated goal is to make anchovies mainstream again.
The opening menu starts with Sicilian street food. Arancini. Panelle, the chickpea fritters, drizzled with honey.
Sfincione palermitano, the Sicilian flatbread with tomato and anchovy. Short-rib sliders. Then it widens out: oysters, clams, mussels, several pastas, a seafood couscous in lobster broth, a whole grilled Mediterranean sea bass, a marinated and breaded wagyu skirt steak.The bucatini con le sarde, the Sicilian classic with sardines, fennel, saffron, and pine nuts, is what most reviewers have been ordering.
The agnello alla agglassato, slow-cooked lamb shank glazed in caramelized onion and Marsala over olive-oil whipped potatoes, is what every reviewer has actually been telling people about afterward. The fried-onion topping does the work the dish needs.There is a tableside cannoli cart. There is a hidden private dining room.
The drink program runs Mediterranean wine, citrus-driven cocktails, and amaro. The room is across the courtyard from Roar Brewing and Barcade, which means the block now has a Sicilian fine-dining restaurant, a Black-owned brewery, an arcade-bar, and SheWolf within a hundred feet of each other. Detroit's most concentrated dining block keeps stacking.644 Selden St., Detroit.
